Lennox-Gastaut Syndrome

Lennox-Gastaut Syndrome (LGS) is a much-feared diagnosis among parents and internet searches for the topic consistently yield stories of despair. LGS is simply a designation for children with a variety of uncontrolled seizures, neurodevelopmental impairment (IQ < 70), and according to most definitions, a specific brain-wave pattern seen on EEG (electroencephalography) called slow spike-and-wave. It is not a predictor of poor outcomes so much as an observation that a child has uncontrolled seizures and already exhibits severe cognitive impairment. Although some children with infantile spasms whose treatment is unsuccessful will eventually carry a diagnosis of LGS, most children with LGS never had infantile spasms in the first place. In some cases, a transition from infantile spasms to LGS can introduce new opportunities for treatment. Several medications, such as runfinamide (Banzel®), are specifically indicated for LGS, and are not effective in treating infantile spasms.


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